Metformin in gestational diabetes mellitus

Comparison of Metformin and Insulin in treatment of Gestational Diabetes Mellitus

Introduction: Gestational Diabetes Mellitus (GDM) is one of the complications of pregnancy that has some maternal and neonatal outcomes. Some drugs such as insulin and oral agents (metformin, ...) are used for management of GDM. The aim of this study was to compare metformin and insulin in treatment of GDM Methods: This clinical trial was carried out in 2009-2011. Sample size was 201 patient...

Maternal and Neonatal Circulating Markers of Metabolic and Cardiovascular Risk in theMetformin in Gestational Diabetes (MiG) Trial Responses to maternal metformin versus insulin treatment

RESEARCH DESIGN AND METHODSdWomen with gestational diabetes mellitus were randomly assigned to metformin or insulin in the Metformin in Gestational Diabetes trial. Fasting maternal plasma glucose, lipids, and CRP were measured at randomization, 36 weeks’ gestation, and 6–8 weeks postpartum as well as in cord plasma. Women with available cord blood samples (metformin n = 236, insulin n = 242) we...

Maternal and Neonatal Circulating Markers of Metabolic and Cardiovascular Risk in the Metformin in Gestational Diabetes (MiG) Trial

OBJECTIVE This study was designed to compare glucose, lipids, and C-reactive protein (CRP) in women with gestational diabetes mellitus treated with metformin or insulin and in cord plasma of their offspring and to examine how these markers relate to infant size at birth. RESEARCH DESIGN AND METHODS Women with gestational diabetes mellitus were randomly assigned to metformin or insulin in the ...

Metformin versus Insulin in the Management of Pre-Gestational Diabetes Mellitus in Pregnancy and Gestational Diabetes Mellitus at the Korle Bu Teaching Hospital: A Randomized Clinical Trial

OBJECTIVE To determine if metformin monotherapy or metformin in combination with insulin is equally effective as insulin monotherapy at glycemic control in diabetes mellitus in pregnancy among Ghanaians. METHODS This was a study involving 104 pregnant women with type 2 diabetes mellitus (T2DM) or gestational diabetes mellitus (GDM) at 20-30 weeks gestation. Participants were randomized into m...

Metformin in Gestational Diabetes Mellitus